Noopept and Alpha GPC vs. Citicoline Stacks

noopept alpha gpc

Noopept is commonly used with Alpha GPC and Citicoline as two excellent sources of Choline. The question that many nootropic users has is which is better to take: Alpha GPC choline or Citicoline (CDP Choline)? In truth, the two are very similar and the effects will be largely indistinguishable. The main difference has to do with the dosage ratios required to stack with Noopept as well as cost.

This article will give you some information on taking Noopept and Alpha GPC or Citicoline to help you decide which is better. Click here to buy Noopept online.

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Noopept Information

Noopept received its patent in 1995. It is a nootropic that works in the same manner as Piracetam; however, Noopept is said to be 1000 times more powerful than Piracetam. With increased use, Noopept becomes more beneficial. It is also considered to have a high oral bioavailability. Noopept appears to have the ability to treat a lot of different cognitive areas that need repairing, but this has not been proven as of yet. This is why researchers are doing more studies to prove that these amazing beliefs about Noopept are true. This is especially the case when it comes to humans.

How Noopept Works

Noopept has four ways in which it works. First, it involves antioxidation. It has been shown that Noopept protects neurons from apoptosis. Secondly, it inhibits glutamate neurotoxicity, which kills cells very fast. It is also associated with neurological conditions such as Alzheimer’s. Third, Noopept increases neuron plasticity. This helps to enhance your learning and memory.

Fourth, Noopept boosts the expression of prolyglycine, cyclo-prolyglycine and phenylacetic acid in the brain. These are all considered to be endogenous nootropics. Using Noopept and Alpha GPC or Citicoline can help to enhance these benefits due to the presence of high levels of choline in these supplements.

Some of the Many Benefits

Noopept is so popular because it has plenty of positive effects and just a handful of negative side effects. Also, it works for both acute and chronic usage. When it comes to vivo and vitro studies, Noopept successfully impacts every stage of your memory. Vitro research proved that Noopept was neuroprotective when it came to H202 and the breakdown of neurons. This applies to those who have healthy brains, as well as those who suffer from conditions such as Down’s syndrome. Read User Reviews of Noopept here.

During rat testing, Noopept was proven to enhance your memory and enhance your learning, which was evidenced by using passive avoidance response testing. Rats that had ischemic lesions were given Noopept for a total of nine days. Then they were tested via passive avoidance response testing. The rats that received treatment did a better job than the control group. This is likely mediated by the acetylcholine pathway which would be synergistically enhanced if you take Noopept with choline supplements like Alpha GPC in a stack.

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Also, Noopept was neuroprotective via antioxidation for the rats that got treatment for the nine days. If they got a dose of Noopept, the rats did better on the passive avoidance test. In another study, the rats that were subjected to olfactory bulbectomies had symptoms that were similar to the ones for Alzheimer’s. But, once the rats used Noopept for 21 days, their spatial memory got much better. This was evident as a result of the Morris Water Maze test.

Noopept’s Mechanisms of Activity

There are other benefits of using Noopept that involve BDNF, NGF and the immune system. When rats were given Noopept, they had a higher MRNA BDNF and NGF expression. Even when they took this supplement for as long as 28 days, there wasn’t any tolerance found. Basically, the benefits of Noopept get better when taken for longer periods. Also, Noopept might be able to reverse immune deficiencies, as evidenced by animal testing. Check out our complete guide on the best way to take Noopept.

Noopept is a peptide that has the ability to cross over the blood brain barrier whenever it is taken orally. It is a member of the Racetam family, but it is much more potent than Piracetam. Taking this supplement leads to anxiolytic benefits because it helps to stimulate dopamine receptors D2 and D3, as well as Ach (Acetylcholine) receptors. This effect will be stronger if taking Alpha GPC with Noopept in stack. In addition, Noopept is thought to provide anti-inflammatory benefits as well.

There are studies that prove that Noopept stimulates proteins that generate new neurons. It also preserves and strengthens any damaged neurons that are located in the hippocampus. Since there is new growth, this means that Noopept might still work long after you stop taking it. Also, it has the ability to activate the NGF and BDNF that is located in a rat’ hippocampus.

There is also one report that claims that Noopept can help to treat Parkinson’s disease because it can alleviate amyloid oligomeric cytotoxicity.

There was another report that compared Noopept and Piracetam dosages. Piracetam was one thousand times lower in strength than Noopept. Also, Noopept had more mneumotropic activity than Piracetam. This just confirms that Noopept is a peptide nootropic that is much stronger than Piracetam.

Noopept Alpha GPC or Citicoline Stack

Noopept is available as a powder, capsule or tablet. You should take about 10 to 30mg of this supplement three times a day. Make sure you follow all directions for taking this supplement. Per rat testing, an effective dosage of Noopept was .01 to 10mgs for rats, and the typical range for humans is 10-30mg. You can take this dosage amount orally or put it up under your tongue for quicker results. The aforementioned dosage of Noopept in rats did not have any toxic effects. As a matter of fact Noopept is believed to be neuroprotective when it comes to dosages.

When adding Alpha GPC or Citicoline to the stack, it is recommended to take between 200 – 400 mg of Alpha GPC and 250 – 500 mg of Citicoline. The difference comes from the fact that Alpha GPC is more bioavailable and therefore stronger. Using a choline source like one of the two listed above can alleviate Noopept headaches that may occur. It will also mean that the benefits of the nootropic supplement are amplified quite dramatically. Alpha GPC in particular has nootropic benefits on its own for focus, memory and mood. However, both are effective and will enhance your results.

There are really no significant differences between the Noopept and Alpha GPC vs. Citicoline stacks and it mostly comes down to preference and price. In most cases, Alpha GPC is more expensive but you also need a smaller dosage for the beneficial effects. You can always try both to determine which is the best one for you.


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