Phenibut vs. Benzodiazepine: Effects, Combos, Cross-Tolerance and Withdrawal

Phenibut vs Benzodiazepine

Phenibut works as an anxiolytic or anti-anxiety medication and it is an over-the-counter suppleemnt. It also works as a nootropics to improve brain function. Nootropics have positive effects on brain chemistry and can not only relieve anxiety but improve cognitive abilities and increase motivation. This is one of the key features that differentiates Phenibut versus Benzodiazepines and other anxiety prescription drugs. This article explains all about phenibut, how it works, the effects it has on the brain and how it may be of help to you. Click here to buy Phenibut online.

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Phenibut for Anti-Anxiety Effects

Phenibut is also known as ?-Phenyl-?-aminobutyric acid, its chemical name and by noofen, its brand name. It’s a nootropic supplement known to relieve stress and anxiety, promote a sense of well-being and enhance sleep. The Russians developed it in the 1960s and phenibut remains widely used throughout Russia due to these benefits (1). It’s gained in popularity in Europe and the US in recent years. It’s easily available for purchase online as are most other nootropics. The dose which is recommended is from 500mg to 1500mg and every individual is different. The dose should be divided up and taken two or three times a day.

Phenibut vs. Benzos

The chemical make-up of phenibut is actually GABA with an added phenyl ring (1). So it is very similar to GABA, a neurotransmitter, but with the added phenyl it is more easily able to penetrate the blood-brain barrier. This allows it to induce its effects of relieving anxiety, which GABA supplements cannot do. It also means it has some similar effects to Benzodiazepines.

Because phenibut’s chemical structure is similar to GABA, it performs like an agonist, in effect stimulating a response from GABA receptors, activating them to function (1). Since GABA is an inhibitory type of neurotransmitter (brain chemical relaying signals) whose job it is to calm nerves by reducing the number of neurons firing at once. Read User Reviews of Phenibut here.

There are two main subgroups of GABA receptors:

• GABAa receptors – can be activated faster than GABAb receptors as fewer steps are needed. These receptors are activated by prescription sedatives such as Xanax, Diazepam and Clonazepam as well as alcoholic beverages.

• GABAb receptors – take longer than GABAa receptors to be activated as it involves more steps. Phenibut is known to activate GABAb receptors so it takes longer to induce the effects.

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Best Way to take Phenibut

Phenibut’s recommended dose is 250mg to 750mg per day, depending on the person (3). The dosage should be divided up and taken throughout the day, either twice or three times a day.

There have been some mild side effects reported such as:

• Dizziness
• Gastrointestinal issues
• Lethargy
• Memory reduction
• Tiredness

These are the same side effects that other supplements and drugs like benzodiazepines acting on GABA receptors report having. In fact, these side effects are relatively mild compared to Benzos.

Check out our complete guide on the best way to take Phenibut.

Phenibut Withdrawal

Reported side effects of withdrawal when people stop taking Phenibut include:
• Increased irritability
• Lethargy
• Negative thoughts
• Nervousness
Therefore it is recommended that people taper off slowly when they stop taking phenibut to minimize or eliminate the symptoms of withdrawal. In some cases, people will take Phenibut pills or powder to help them taper off using Benzos while avoiding withdrawal symptoms.

Phenibut should NEVER BE TAKEN in conjunction with benzodiazepenes or alcoholic beverages as this can bring about respiratory depression which can cause unconsciousness and subsequent death. The Phenibut and benzo combo should be avoided so that no serious side effects occur.


Phenibut – Nootriment

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