Review for Stacking Pramiracetam and Choline Together

stacking pramiracetam and choline

Pramiracetam stands out as one of the most effective nootropics in use today. It’s used for boosting focus and concentration while improving the retention, processing and recall of information. Observations indicate that Pramiracetam works by modulating the action of the neurotransmitter acetylcholine.

One dose of Pramiracetam increases the uptake of choline in the cerebral cortex and in the hippocampus which is the area of the brain used for forming memories. Because of this the supplement works a lot more effectively when stacked with Choline. Click here to buy Pramiracetam online.

Pramiracetam300 mg x 30 capsules
By Absorb Health
$22.99 ($0.76 / dose)
★★★★★ (100)
  • Enhance focus
  • Promote memory
  • Mental clarity
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Why Stack Choline with Pramiracetam?

Experienced users of nootropics commonly stack their favorite racetam with a good quality Choline for maximum effect. Because Choline is an acetylcholine precursor this increases the power while mitigating the common side effect of headaches. Choline on its own is known to provide a cognitive boost for people deficient in this nutrient. When you’re stacking Pramiracetam and Choline the ratio is critically important. If the wrong ratio is used the side effects may be exaggerated or they’re might be no benefit to taking them at all.

The Benefits of Pramiracetam Stacks

It is estimated that Pramiracetam is approximately 30 times stronger than Piracetam, the drug from which it’s been derived. Therefore the dosage needed to get the boost you’re looking for is much smaller than with Piracetam. It’s for the most part thought to be non-toxic and perfectly safe when taken long-term. It’s not recommended that anyone take more than the recommended dose but even if they did it wouldn’t improve the effects according to users.

The effect of taking Pramiracetam is improved mental functions such as focus, alertness and memory. Some users claim they’ve felt an improved mood as well. This nootropic does not interact with dopamine or serotonin, which are usually associated with an improved mood. Many of those who’ve used Pramiracetam claim they felt a blunting of their emotions similar to the effects of Ritalin, an ADHD drug. Read User Reviews of Pramiracetam here.

When using Pramiracetam mental focus is easy and spatial memory is usually enhanced. This is very useful for students studying stacks of books for an important project or exam. They will be able to absorb the material easily and remember the information more accurately and with increased speed.

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Our Brains Need Choline

The precursor to the vital neurotransmitter Acetylcholine is Choline. Acetylcholine is involved in the formation of memories, the consolidation of information and the ability to remember it. With higher levels of acetylcholine, distractions are inhibited which makes it easier to pay full attention and focus on the task at hand.

In the past it was assumed that humans received ample amounts of Choline in their diet, but it’s been discovered that a large number of humans are actually deficient in Choline. The foods which do provide high amounts of Choline are liver, tofu, broccoli, eggs, sunflower seeds and brewer’s yeast.

Between the ages of 20 and 30 levels of Acetylcholine in the brain start to decline which might be an indicator of Alzheimer’s disease in the future. A deficiency of Choline in the brain can be the cause of headaches, insomnia, fatigue and a foggy brain in general. Pregnant women who are deficient in Choline have a higher risk of neural tube defects in their babies because Choline is essential in the development of the fetal nervous system.

Use Pramiracetam with Alpha GPC or Citicoline

When taking as a nutritional supplement, Choline provides the brain with the fuel essential for functioning optimally and with clarity. This is even truer when stacking with Pramiracetam because the brain does need additional acetylcholine to accommodate the increase in mental activity and specifically the added neuronal communication

There are a number of different forms of Choline on the market, but they’re not all equal in terms of efficiency because of the varied bio-availability. The two forms which are recommended are Citicoline and Alpha-GPC. Both of these have the ability to penetrate the blood-brain barrier in larger quantities which means they’re able to convert to acetylcholine. Check out our complete guide on the best way to take Pramiracetam.

Doses to Take

When Pramiracetam and Choline are stacked together the combination is very sensitive to the ratio between the two in terms of dosage. Many users of racetam supplement with Choline if and when they start getting headaches. These are assumed to be caused by the increase in the activity of acetylcholine in the brain. Once Choline is added to Pramiracetam the headaches disappear. Because of the potency of Pramiracetam, the majority of users supplement with Citicoline or Alpha-GPC to provide the needed Choline for their brains.

Our recommendation is to begin with a 2:1 ratio, Pramiracetam to Citicoline:
• 200mg of Pramiracetam
• 100mg of Citicoline

Because Pramiracetam is fat soluble, the supplement should be taken with a source of fat to make sure it is absorbed from the intestines into the bloodstream. Take the powder dissolved in a glass of milk or take it after a meal containing some fat.

Racetams take time to bring out the desired effect although Pramiracetam seems to work more quickly when compared to other Racetams. We recommend you take your stack for a few days before adjusting the ratio if you think it’s necessary. You should increase your dose of Pramiracetam to 250mg and the Citicoline to 125mg. Make the adjustments gradually over a period of time. Do not rush this process. The dosage of Pramiracetam should never exceed a maximum of 400mg. Because this is a very potent nootropic there are possible side effects that could occur at higher levels.


When users begin with a ratio of 2:1 and titrate as needed users can expect to experience an acutely focused and improved cognitive state. Every individual has a different biochemistry so the perfect Pramiracetam Choline ratio for stacking will vary. These nootropics intensify the positive effects of each other to improve intelligence, mental fluidity and focus while enhancing clarity of thought in a very profound manner.

Although it doesn’t work by stimulating the Central Nervous system the majority of users claim they have increased motivation and energy when they take this stack. The Pramiracetam Choline Stack is very effective when someone is involved in a mentally draining task for an extended period of time like studying or being involved in the critical analysis of a complicated project.


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