Sunifiram Benefits for Memory, Focus and Mood
Having a molecular structure similar to that of Piracetam, Sunifiram is a relative newcomer to the world of nootropics. The first studies on Sunifiram effects were published in 2000, and there are currently no human clinical studies that have been done on it. Based on the studies that have been done on Sunifiram so far, it seems to be much more potent than Piracetam. Early animal studies on Sunifiram suggest its potential in treating amnesia and improving general cognitive ability. User reviews say that Sunifiram is good for enhanced memory, focus and for promoting better mood and alleviating stress. Click here to buy Sunifriam online.
Scientists don’t fully understand yet how nootropics work, and the same is true for Sunifiram. However, studies that have been conducted so far indicate Sunifiram may work in two main ways:
Sunifiram has a structure similar to the structure of other ampakines. As an ampakine, it primarily works to stimulate AMPA receptors. In studies conducted on lab animals, subjects were given NBQX, a known AMPA antagonist. They were then given Sunifiram, and the effects of NBQX were reversed. As an AMPA agonist, Sunifiram benefits may also have potential in improving memory and increasing learning ability, as well as improving attention span and heightening alertness. However, there have been no actual studies done to verify or refute these claims.
Along with its similarity to ampakines, evidence from one study performed on rats shows Sunifiram can increase levels of acetylcholine in the cerebral cortex. As a supplement that influences the Cholinergic system, Sunifiram may improve decision making ability, as well as the ability to transfer information from short-term to long-term memory.
It may also improve motor skills by increasing conscious control over muscle contraction. More studies are needed before these benefits can be validated. Read User Reviews of Sunifriam here.
Most of the studies conducted on Sunifiram to date suggest its use for treating amnesia, as well as its potential for the treatment of Alzheimer’s, when compared to other racetam class drugs. When compared Piracetam, the original nootropic and the one against which all others are compared, milligram for milligram, Sunifiram is shown to be about 1000 time more powerful than Piracetam.
In one study, researchers administering certain drugs known to cause amnesia, including mecamylamine, baclofen, clonidine, and scopolamine, to mice. After administration of these drugs, the mice were run through the Morris Water Maze test and tested on their ability to escape. They were then run through the Morris Water Maze after given different doses of Sunifiram.
Researchers discovered that the mice that were given Sunifiram had much better escape latency scores, indicating a reduction in amnesiac effects from the scopolamine. The researchers determined that Sunifiram may be able to slow cognitive decline, but have so far have not been able to determine what effects Sunifiram may have on otherwise healthy individuals.
Additional Studies of Benefits
Another study used bulbectomized mice. A bulbectomy is a surgical procedure during which the part of the brain responsible for smell is removed. This type of procedure is done to study the effects of antidepressants, as removal of the olfactory bulb is known to cause symptoms of depression in mice. The mice were tested on memory using the Y-Maze test and Novel Object Recognition test. The scores of mice who had been given Sunifiram were compared with the scores of mice who had not been given the supplement. Check out our complete guide on the best way to take Sunifriam.
The researchers discovered that bulbectomized mice treated with Sunifiram prior to the test had significantly higher scores than the bulbectomized mice who had not been given Sunifiram.
When testing the effects and benefits of Sunifiram on depression, olfactory bulbectomized mice were put through the Tail Suspension test. Researchers found no significant difference between the experimental and control groups on this test. The research revealed some compelling neurochemical changes: the phosphorylation of CaMKII?, GluR1, PKC?, and NR1 in bulbectomized mice returned to control levels when they were given Sunifiram. All of these neurochemicals have been shown to be involved in memory and learning.
In the trials that have been done on mice, the researchers orally administered doses of 0.01-0.1 mg/kg. After allometric scaling, this converts to roughly .09mg/kg in humans, or about 6mg for a 150lb person. Sunifiram benefits are best when sticking to this recommended dosage and will not increase if you take larger amounts.